Close Menu
bkngpnarnaul
  • Home
  • Education
    • Biology
    • Chemistry
    • Math
    • Physics
    • Science
    • Teacher
  • E-Learning
    • Educational Technology
  • Health Education
    • Special Education
  • Higher Education
  • IELTS
  • Language Learning
  • Study Abroad

Subscribe to Updates

Please enable JavaScript in your browser to complete this form.
Loading
What's Hot

How to Use Socratic Seminars in High School + Lesson Examples

August 9, 2025

How the Red Planet craze started 120 years ago: Interview with ‘The Martians’ author David Baron

August 9, 2025

The Situation at Columbia XXXI

August 9, 2025
Facebook X (Twitter) Instagram
Sunday, August 10
Facebook X (Twitter) Instagram Pinterest Vimeo
bkngpnarnaul
  • Home
  • Education
    • Biology
    • Chemistry
    • Math
    • Physics
    • Science
    • Teacher
  • E-Learning
    • Educational Technology
  • Health Education
    • Special Education
  • Higher Education
  • IELTS
  • Language Learning
  • Study Abroad
bkngpnarnaul
Home»Physics»Uncovering the hidden emerging pathogen behind Aspergillosis cases in Japan
Physics

Uncovering the hidden emerging pathogen behind Aspergillosis cases in Japan

adminBy adminJuly 17, 2025No Comments4 Mins Read0 Views
Share Facebook Twitter Pinterest LinkedIn Tumblr Email WhatsApp Copy Link
Follow Us
Google News Flipboard Threads
Uncovering the hidden emerging pathogen behind Aspergillosis cases in Japan
Share
Facebook Twitter LinkedIn Pinterest Email Copy Link


Uncovering the hidden emerging pathogen behind Aspergillosis cases in Japan
Through extensive phylogenetic analyses based on utilizing cloned copies of the calmodulin gene, researchers have mapped the evolutionary genetic relationships between Aspergillus spinulosporus and A. sublatus strains, giving rise to the allodiploid hybrid A. latus strain. Credit: Professor Hiroki Takahashi from Chiba University, Japan

Aspergillus is a fungus that is commonly found in the environment, both indoors and outdoors. This fungus species can cause aspergillosis—a respiratory infection affecting the lungs. A. fumigatus, A. nidulans, and A. niger are some of the common species within the Aspergillus genus that cause aspergillosis. In high-risk populations, such as immunocompromised individuals, aspergillosis can be life-threatening and lead to poor patient outcomes.

Previous research studies have identified A. latus as an allodiploid hybrid species containing gene sequences from two distinct species: A. spinulosporus and an unknown species related to A. quadrilineatus. Owing to its allodiploid hybrid nature, A. latus has been associated with both colonization and clinical disease, including invasive pulmonary aspergillosis, and some strains have shown reduced susceptibility to antifungal agents. Recent reports indicate that certain European and American aspergillosis cases could be attributed to A. latus. However, to date, A. latus strains have not been identified in clinical samples of patients in Japan.

To identify and characterize A. latus strains from clinical isolates and address the concerns around cryptic species of Aspergillus that lack definite and observable morphological characteristics, a team of researchers led by Associate Professor Hiroki Takahashi from the Medical Mycology Research Center, Chiba University, Japan, has conducted a new study. The research team comprised Dr. Saho Shibata, Dr. Momotaka Uchida, and Dr. Takashi Yaguchi from the Medical Mycology Research Center, Chiba University, along with Dr. Vit Hubka from the Czech Academy of Sciences, Czech Republic. Their findings were published in the journal Medical Mycology on June 10, 2025.

“The complexity of fungal pathogens and their resistance mechanisms presents both a fascinating scientific challenge and an important public health issue, which I am eager to explore,” says Dr. Takahashi, explaining the motivation behind the present study. Initially, the researchers analyzed 23 A. spinulosporus strains, which were collected between 2012 and 2023.

To accurately identify A. latus strains among the samples, the team utilized comprehensive phenotyping and genome sequencing analysis. The team identified seven A. latus strains among the 23 samples, which are clinically significant given that A. latus strains were not previously reported in Japan. Furthermore, through phylogenetic analyses, they observed that while one copy of the calmodulin gene aligned with the genetic sequence of A. spinulosporus, the other copy clustered with A. sublatus.

Inspired by their findings, the researchers went a step further and conducted antifungal susceptibility testing of different Aspergillus strains to antifungal medications. Japanese strains of A. latus showed reduced susceptibility to caspofungin and amphotericin B drugs. Also, genomic analysis revealed multiple amino acid insertions and deletions in one of the two alleles of the fks1 gene, which encodes a key component of the fungal cell wall biosynthesis machinery. This fks1 gene is associated with resistance to echinocandin-class antifungal drugs.

The researchers suggest that if overlapping nucleotide signals are observed during gene sequencing—such as double peaks indicating the presence of two distinct alleles—then the possibility of hybrid species like A. latus should be considered in the diagnostic evaluation.

Highlighting the potential applications of the present study, Dr. Takahashi states, “By incorporating molecular phylogenetic and genomic analyses into diagnostic systems, our research is expected to improve the accuracy of fungal infection diagnoses and enable the selection of the most appropriate antifungal treatments for individual patients.”

Taken together, this study provides significant observations regarding the clinical relevance, prevalence, and potential role of A. latus as a disease-causing agent. Improved and reliable molecular diagnostic tools are vital for the accurate identification of A. latus strains and the subsequent management of aspergillosis.

More information:
Saho Shibata et al, Aspergillus latus: A cryptic causative agent of aspergillosis emerging in Japan, Medical Mycology (2025). DOI: 10.1093/mmy/myaf052

Provided by
Chiba University

Citation:
Uncovering the hidden emerging pathogen behind Aspergillosis cases in Japan (2025, July 17)
retrieved 17 July 2025
from

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

Aspergillosis cases emerging Hidden Japan Materials Nanotech pathogen Physics Physics News Science Science news Technology Technology News Uncovering
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email WhatsApp Copy Link
yhhifa9
admin
  • Website

Related Posts

Physics

The Situation at Columbia XXXI

August 9, 2025
Physics

Physicist Paul Richards, a pioneer in studies of the cosmic microwave background, dies at 90

August 8, 2025
Physics

Lloyd Espenschied’s Library of Electrical History

August 7, 2025
Physics

Cystadleuaeth Sêr y Gofod – Physics and Astronomy outreach

August 6, 2025
Physics

Famous double-slit experiment holds up when stripped to its quantum essentials » MIT Physics

August 5, 2025
Physics

Brownian Motions and Quantifying Randomness in Physical Systems

August 4, 2025
Add A Comment
Leave A Reply Cancel Reply

Top Posts

2024 in math puzzles. – Math with Bad Drawings

July 22, 202513 Views

Testing Quantum Theory in Curved Spacetime

July 22, 20257 Views

How AI Is Helping Customer Support Teams Avoid Burnout

May 28, 20257 Views

What Is The Easiest Language To Learn? Your Guide And Quiz

June 30, 20255 Views
Don't Miss

AIFS Abroad Student Spotlight: Savannah’s Summer in Paris 

By adminAugust 7, 20258

10 Eager to follow in the footsteps of a college student who studied abroad in…

Amiya’s Spring Semester in Barcelona

August 3, 2025

Why I Fell in Love with Ireland | Study in Ireland

August 2, 2025

Meet College Students Who Did a Study Abroad Program in Ireland

July 30, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo

Subscribe to Updates

Please enable JavaScript in your browser to complete this form.
Loading
About Us
About Us

Welcome to Bkngpnarnaul. At Bkngpnarnaul, we are committed to shaping the future of technical education in Haryana. As a premier government institution, our mission is to empower students with the knowledge, skills, and practical experience needed to thrive in today’s competitive and ever-evolving technological landscape.

Our Picks

How to Use Socratic Seminars in High School + Lesson Examples

August 9, 2025

How the Red Planet craze started 120 years ago: Interview with ‘The Martians’ author David Baron

August 9, 2025

Subscribe to Updates

Please enable JavaScript in your browser to complete this form.
Loading
Copyright© 2025 Bkngpnarnaul All Rights Reserved.
  • About Us
  • Contact Us
  • Disclaimer
  • Privacy Policy
  • Terms and Conditions

Type above and press Enter to search. Press Esc to cancel.