
If you’re looking for a lesson that blends chemistry, physiology, history, and human stories in a way that truly resonates with students, the Canary Girls case study is a standout resource for your classroom. Based on the historical accounts featured in the book Canary Girls, this case study invites students to explore the real experiences of women who worked in WWI munitions factories, and the science behind the startling yellow appearance that earned them their nickname.
This lesson isn’t just another historical reading. It’s a vivid, interdisciplinary look at chemical exposure, occupational hazards, and women’s roles in wartime, all through the lens of a gripping true story.
A Case Study in Biochemistry and Toxicology
The Canary Girls provide an extraordinary window into how chemistry affects the body. Students are instantly hooked by the question: “Why did their skin turn yellow?”

From there, the case study guides students through:
- The chemical structure of TNT and why it is easily absorbed through skin
- How TNT reacts with proteins and fats, creating the yellow discoloration
- Physiological effects such as anemia, cyanosis, and liver damage
- The historical context of women entering dangerous industrial jobs during wartime
- What workplace safety looked like in the early 1900s — and how far we’ve come
Engaging Features for Students
The case study includes:
- A compelling narrative introduction students want to read
- Clear explanations of the mechanisms of TNT toxicity
- A student worksheet and discussion questions that encourage critical thinking
- A clean, educational graphic explaining TNT exposure
- Historical background that brings the story alive
- An infographic on the physiology of TNT exposure
If you want to inspire your students with a case study that blends chemistry, history, storytelling, and real-world relevance, this is a fantastic addition to your teaching toolkit. It’s vivid, informative, and grounded in an unforgettable piece of history.
Related Resources
Video Gallery: “A Day in the Life of a Munitions Worker”
Canary Girls: A Historical Fiction Novel of Courage and Camaraderie Among Women in World War I
Chicago Cyanide Murders – case study on mysterious deaths caused by cyanide
Ethanol and Methanol During Prohibition – excerpt from Poisoner’s handbook with questions
