Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Environment, evolution and development

Cell Biology

Modelling

Tools & Resources

Research practice and education

Developmental biology

| Patterning & signalling

Skin capillary endothelial cells form a network of spatiotemporally conserved Ca2+ activity
Anush Swaminathan, David G. Gonzalez, Catherine Matte-Martone, Fei Xu, Deandra Simpson, David Monedero-Alonso, Jessica L. Moore, Julia J. Mack, Chen Yuan Kam, Valentina Greco

The pro-inflammatory cytokines IFN-α and TNF-α inhibit organoid-derived extravillous trophoblast invasion
A. Jantine van Voorden, Fangxu Lin, Souad Boussata, Remco Keijser, Liana Barenbrug, Bente Horselenberg, Ans M. M. van Pelt, Wendy Dankers, Susana M. Chuva de Sousa Lopes, Gijs B. Afink

Differential spreading behaviors of Nodal signalling molecules in the extracellular space cooperatively shape left-right asymmetry
Takafumi Ikeda, Toru Kawanishi, Yusuke Mii, Taijiro Yabe, Jose Pelliccia, Rebecca D Burdine, Hiroyuki Takeda

CD44 facilitates adhesive interactions in airineme-mediated intercellular signaling
Raquel L Bowman, Jiyea Kim, Michael J Parsons, Dae Seok Eom

Temporal requirements of MAPK effectors reflect signalling microenvironment heterogeneity during Mesp1+ cardiac progenitor emergence and migration
Nitya Nandkishore, Sinem Eylem Inal, Adeline Ghata, Fabienne Lescroart

Dynamic polarization of heparan sulfate proteoglycans is involved in planar cell polarity and localization of endogenous Wnt11 during vertebrate neural tube formation
Minako Suzuki, Ritsuko Takada, Tomoe Kobayashi, Makoto Matsuyama, Shinji Takada, Yusuke Mii

Emergence of cell polarity by reciprocal interactions between Wnt and core PCP components
Yusuke Mii, Minako Suzuki, Hiroshi Koyama, Kei Nakayama, Ritsuko Takada, Tomoe Kobayashi, Motosuke Tsutsumi, Tomomi Nemoto, Makoto Matsuyama, Toshihiko Fujimori, Shinji Takada

Loss of Twist impairs tentacle development and induces epithelial neoplasia in the sea anemone Nematostella vectensis
Patricio Ferrer Murguia, Julia Hagauer, Emmanuel Haillot, Aissam Ikmi, Alison G Cole, Ulrich Technau

3D epithelial cell topology tunes signalling range to promote precise patterning
Giulia Paci, Francisco Berkemeier, Buzz Baum, Karen M. Page, Yanlan Mao

Dual pathway regulation of castration response and ferroptosis in the prostate epithelium
Weiping Li, Jing-Bo Zhou, Zejian Wang, Fereshteh Zandkarimi, Teresa A. Milner, Shouhong Xuan, John R. Christin, Caroline J. Laplaca, Andrew S. Greenberg, John P. Chute, Hanina Hibshoosh, Brent R. Stockwell, Michael M. Shen

Wntless interacts with Notch signaling to balance the generation of neurons and gliocytes in vertebrate dorsal diencephalon
Shu-Heng Lin, He-Yen Pan, Bo-Tsung Wu, Joe Sakamoto, Chun-Hsiu Wu, Atsuko Shimada, Yasuhiro Kamei, Hiroyuki Takeda, Yung-Shu Kuan

Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesis
Irene Garcia-Gonzalez, Susana F. Rocha, Filipa V. Oliveira, Mariya Lytvyn, Maria S. Sanchez-Muñoz, Aroa Garcia-Cabero, Taija Mäkinen, Rui Benedito

A dual role for GLI3 signaling in neural crest development
Simon J. Y. Han, Vinit Adani, Edward Farrow, Bhavalben Parmar, Ching-Fang Chang, Kim Cochran, Paige J. K. Ramkissoon, Ezekiel Esteban, Kelsey H. Elliott, Kevin A. Peterson, Brian Gebelein, Martín García-Castro, Samantha A. Brugmann

MAPK/ERK signaling blocks ectopic H3K9me3 heterochromatin formation to confer mesoderm and endoderm developmental competence
Satoshi Matsui, Marissa Granitto, Samuel Sampson, Gerardo Mirizio, Ryo Maeda, Makoto Tachibana, Christopher Ahn, Hee-Woong Lim, Makiko Iwafuchi

Caenorhabditis elegans Uses Canonical and Non-canonical Hippo signaling
Linh Huynh, Razan A. Fakieh, C’Brionne Hendrix, Reid Powell, David J. Reiner

Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut
Jiaying Lv, Xingting Guo, Rongwen Xi

Cell-cell communication as underlying principle governing color pattern formation in fishes
Marleen Klann, Saori Miura, Shu-Hua Lee, Stefano Davide Vianello, Robert Ross, Masakatsu Watanabe, Emma Gairin, Yipeng Liang, Harrison W. Hutto, Braedan M. McCluskey, Marcela Herrera, Lila Solnica-Krezel, Laurence Besseau, Simone Pigolotti, David M. Parichy, Masato Kinoshita, Vincent Laudet

Spen and Nito prevent dedifferentiation of progenitors by translationally repressing E(Spl)mγ
Xiaosu Li, Wenwen Lu, Marisa Connell, Xiaobing Deng, Sijun Zhu

Novel Roles of Sonic Hedgehog Signaling in Retinal Patterning and Neurogenesis During Mammalian Eye Development
Miranda R. Krueger, Simranjeet K. Cheema, Sergi Simo, Edward M. Levine, Nadean L. Brown, Anna La Torre

Angptl5 restricts primitive hematopoiesis by modulating retinoic acid signaling in zebrafish
Jing Mo, Ding-Hao Zhuo, Ying Huang, Tao Cheng, Yang Dong, Yan-Yi Xing, Yun-Fei Li, Zi-Xin Jin, Xiang Liu, Guo-Qin Zhao, Hai-Rong Pu, Yu-Meng Liu, Zhi-Xu He, Li-Ping Shu, Peng-Fei Xu

Microglia and Chek2 contribute to sex-specific organization of the adult zebrafish brain
Paloma Bravo, Florence L. Marlow

| Morphogenesis & mechanics

Endothelial-zippering proceeds by sensing heartbeat-driven force through Cadherin-6 during heart-vessel connection in zebrafish
Moe Fukumoto, Haruko Watanabe-Takano, Hajime Fukui, Ayano Chiba, Keisuke Sako, Hiroyuki Nakajima, Naoki Mochizuki

Mechanical conditions preventing live cell extrusion during primary neurulation in amniotes
Santiago A. Bosch Roascio, Julio A. Hernández, Flavio R. Zolessi

Dachsous-Fat Signaling Shapes the Drosophila Wing through Mechanical Forces
Bipin Kumar Tripathi, Zhenru Zhou, Kenneth D. Irvine

Epiblast Lumenogenesis is not a mammalian-specific trait
Antonia Weberling, Natalia A. Shylo, Hannah Wilson, Melainia McClain, Richard Kupronis, Alex Muensch, Suzannah A. Williams, Florian Hollfelder, Paul A. Trainor

Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation
Morena Raiola, Miquel Sendra, Jorge Nicolás Dominguez, Miguel Torres

Gastruloids employ an alternative morphogenetic route to generate a posterior body axis on adherent substrates
Guillermo Serrano Nájera, Apolline Delahaye, Benjamin J. Steventon

Depletion of a neural cell adhesion molecule disrupts both epithelial and germ layer identity in sea anemone embryos
Anna Postnikova, Julissa Tello, Maristhela Alvarez, Grace Lee, Ilhan Ali, Christine M Field, Timothy J Mitchison, Katerina Ragkousi

STAT3 regulates basal cell identity and morphogenesis during early esophageal development
Secunda W. Kariuki, Yosuke Mitani, Dominique D. Bailey, Gizem Efe, Ved V. Tripathi, Halil Tekin, Kensuke Suzuki, Jianwen Que, Joel Gabre, Ricardo Cruz-Acuña

Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signaling
Giada Vanni, Anna Citron, Ambela Suli, Paolo Contessotto, Robin Caire, Alessandro Gandin, Giovanna Mantovan, Francesca Zanconato, Giovanna Brusatin, Michele Di Palma, Elisa Peirano, Lisa Sofia Pozzer, Carlo Jr. Albanese, Roberto A. Steiner, Michelangelo Cordenonsi, Tito Panciera, Stefano Piccolo

Directional cell motility facilitates side-branching in the mammary epithelium in a tension-sensitive manner
Beata Kaczyńska, Qiang Lan, Marja L. Mikkola, Satu-Marja Myllymäki

Patterns of Mitochondrial ATP Predict Tissue Folding
Bezia Lemma, Megan Rothstein, Pengfei Zhang, Bridget Waas, Marcus Kilwein, Safiya Topiwala, Sherry X. Zhang, Anvitha Sudhakar, Katharine Goodwin, Elizabeth R. Gavis, Ricardo Mallarino, Andrej Kosmrlj, Celeste M. Nelson

Bidirectional translocation of actomyosin drives epithelial invagination in ascidian siphon tube morphogenesis
Jinghan Qiao, Pengyu Yu, Hongzhe Peng, Wenjie Shi, Bo Li, Bo Dong

Corneal lens curvature depends on localized chitin secretion
Neha Ghosh, Jessica E. Treisman

The Optic cup is actively shape programmed by independently patterned apical forces
Ana Patricia Ramos, Lior Moneta, Alicja Szalapak, Louise Dagher, Malcolm Hillebrand, Carl D. Modes, Caren Norden

| Genes & genomes

Intron retention is dynamically regulated during zebrafish larval development and disrupted by high-fat diet
Jesús Gómez-Montalvo, Jesus Hernandez-Perez, Cecilia Zampedri, Samantha Carrillo-Rosas, Daniela Fernanda Suárez-Bernal, Paula Marroquín-Morales, Marian Farrera-Borraz, Silvia Hinojosa-Alvarez, C. Fabián Flores-Jasso, Rocio Alejandra Chavez-Santoscoy, S. Eréndira Avendaño-Vázquez, Jose Mario Gonzalez-Meljem

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels
Ryan N. Allsop, Jeffrey Boeren, Beatrice F. Tan, Sarra Merzouk, Suresh Poovanthingal, Wilfred F.J. van IJcken, Jeroen A.A. Demmers, Hegias Mira Bontenbal, Cristina Gontan, Joost Gribnau, Vincent Pasque

Genome-wide association study shows developmental robustness control by intestinal maltase via internal environment in Drosophila
Soshiro Kashio, Izumi Enoki, Yuto Yoshinari, Takashi Nishimura, Masayuki Miura

HDAC3 prevents enhancer hyperactivation to enable developmental transitions
Nikolaos Stamidis, Anne Wenzel, Konrad Kacper Uściło, Smaragda Kompocholi, Sandra Bages-Arnal, Gemma Noviello, Lea Haarup Gregersen, James Alexander Hackett, Jan Jakub Żylicz

Species-specific chromatin architecture and neurogenesis mediated by a human enhancer
Federica Mosti, Jing Liu, Katie Lam, Samantha Skavicus, Victoria A. Kapps, Ketrin Gjoni, Nicholas S. Heaton, Katherine S. Pollard, Debra L. Silver

Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation
Jielin Yan, Hyein S. Cho, Renhe Luo, Michael A. Beer, Wei Li, Danwei Huangfu

Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans
Marilina Raices, Fabiola Balmir, Nicola Silva, Wei Li, McKenzie K. Grundy, Dane K. Hoffman, Elisabeth Altendorfer, Carlos Jaime Camacho, Kara A. Bernstein, Monica P. Colaiácovo, Judith L. Yanowitz

Chromatin priming by transcription factor ELF3 awakens latent competence for human amniotic differentiation
Masatoshi Ohgushi, Kaori Honda, Hitoshi Niwa, Mototsugu Eiraku

Transcriptional repression of central spindle factors controls endomitosis in the C. elegans intestine
Ramon Barrull-Mascaró, Sonia Veltkamp, Samia Boutaibi, Lotte M. van Rijnberk, Rebecca Lippmann, Matilde Galli

Specialised super-enhancer networks in stem cells and neurons
Izabela Harabula, Liam Speakman, Francesco Musella, Luca Forillo, Luna Zea-Redondo, Alexander Kukalev, Robert A Beagrie, Kelly J. Morris, Lucas Fernandes, Ibai Irastorza-Azcarate, Ana M. Fernandes, Silvia Carvalho, Dominik Szabó, Carmelo Ferrai, Mario Nicodemi, Lonnie Welch, Ana Pombo

Genome-wide screen for deficiencies modifying Cyclin G-induced developmental instability in Drosophila melanogaster
Valérie Ribeiro, Marco Da Costa, Delphine Dardalhon-Cuménal, Camille A. Dupont, Jean-Michel Gibert, Emmanuèle Mouchel-Vielh, Hélène Thomassin, Neel B. Randsholt, Vincent Debat, Frédérique Peronnet

Chamber-Specific Transcriptomic Insight into Cardiac Development using Guinea Pig and Human Heart Tissue
Shatha Salameh, Devon Guerrelli, Luther Swift, Anika Haski, Alisa Bruce, Manan Desai, Yves d’Udekem, Nikki Gillum Posnack

Genome-wide chromatin recording resolves dynamic cell state changes
Yodai Takei, Jordan A. Lay, James M. Linton, Duncan M. Chadly, Yoshiki Ochiai, Ron Hadas, Andrew A. Perez, Mario R. Blanco, Paola Laurino, Mitchell Guttman, Michael B. Elowitz

ATAC-seq of Low-Input and Cryopreserved Primordial Germ Cells Reveals Functional Enhancers
Akane Kawaguchi, Mao Igari, Yasuto Murayama, Hiroko Iikawa, Mika Sakamoto, Yasukazu Nakamura, Shigehiro Kuraku, Keisuke Ishihara, Daisuke Saito

REFEE Shapes ZGA Through Post-Transcriptional Regulation of Repetitive RNAs in Mouse Embryos
Mie Kobayashi-Ishihara, Akihiko Sakashita, Youjia Guo, Hirotsugu Ishizu, Hidetoshi Hasuwa, Ten D. Li, Toshiya Nakahara, Tomohiro Kitano, Hidetaka Kosako, Kensaku Murano, Haruhiko Siomi

Nanos downregulates maternal mRNAs in germline during Drosophila early embryogenesis
Yasuhiro Kozono, Makoto Hayashi, Miho Asaoka, Satoru Kobayashi

| Stem cells, regeneration & disease modelling

Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease
Irfan S. Kathiriya, Kavitha S. Rao, Alexander P. Clark, Kevin M. Hu, Zoe L. Grant, Megan N. Matthews, Zhe Chen, Jeffrey J. Saucerman, Swetansu K. Hota, Benoit G. Bruneau

Obesogenic diet alters decidual differentiation and cell-cell communication in the mouse uterus
Burak Koksal, Christian J. Bellisimo, Patrycja Jazweic, Deborah M. Sloboda, Alexander G. Beristain

Momordica charantia Prevents Reproductive and Neurological Dysfunctions in Drosophila melanogaster Models of Type 2 Diabetes
A.M. Agi, R. Abdulazeez, N. Abdulasalam, M.B. Omobalaji, O.S. Haruna, D.M. Shehu

Patient-derived airway organoids from BAL fluid model injury and therapy responses in neonatal bronchopulmonary dysplasia
Shilpa Sonti, Abiud Cantu, Manuel Cantu Guttierez, Connor Leek, Phinzy Pelton, Erik A. Jensen, Krithika Lingappan

Systemic administration of a reported extracellular vesicle inhibitor, dimethyl amiloride, induces preterm birth and fetal growth restriction in pregnant mice
Madison L. Stone, Scout Bowman-Gibson, Mili S. Bhakta-Yadav, Thomas L. Brown

Neural Progenitors as a Novel Pathogenic Mechanism in Microcephaly
Rami Yair Tshuva, Jeyoon Bok, Mio Nonaka, Xufeng Xue, Bidisha Bhattacharya, Aditya Kshirsagar, Tsviya Olender, Miri Danan-Gotthold, Tamar Sapir, Jianping Fu, Orly Reiner

Glial betaPix is essential for blood vessel development in the zebrafish brain
ShihChing Chiu, Qinchao Zhou, Chenglu Xiao, Linlu Bai, Xiaojun Zhu, Wanqiu Ding, Jing-Wei Xiong

Developmental outflow tract abnormalities of Jag1-deficient mice are associated with abnormal ventricular activation and desynchronized contraction
Kristýna Neffeová, Eva Nekvindová, Veronika Olejníčková, Hana Kolesová

Human ectodermal organoids reveal the cellular origin of DiGeorge Syndrome
Ed Zandro M. Taroc, Surangi Perera, Tunde Berecz, Jenny Hsin, Karla Barbosa-Sabanero, Sravya Pailla, Zarin Zainul, Ceren Pajanoja, Agota Apati, Daniel Martin, Laura Kerosuo

Stem-cell modeling of cerebellar dysfunction of Angelman syndrome
Carina Maranga, Adriana A. Vieira, João Camões dos Santos, Teresa P. Silva, Joana Gonçalves-Ribeiro, Karim Chebli, Miguel Casanova, Maud Borensztein, Laura Steenpass, Sandra H. Vaz, Tiago G. Fernandes, Simão T. da Rocha, Evguenia P. Bekman

Characterisation of lmx1b paralogues in zebrafish reveals divergent roles in skeletal, kidney, and muscle development
Joanna J. Moss, Chris R. Neal, Erika Kague, Jon D. Lane, Chrissy L. Hammond

Disturbed mitochondrial maturation in cardiolipin remodeling-deficient cardiomyocytes
Nanami Senoo, Macie S. Sheridan, Yvonne Wohlfarter, Mackenzie T. Primrose, Emmanouil Tampakakis, Markus A. Keller, Steven M. Claypool

The Placental Transcriptome Serves as a Mechanistic Link between Prenatal Phthalate Exposure and Placental Efficiency
Mariana Parenti, Samantha Lapehn, James MacDonald, Theo Bammler, Adam Szpiro, Marnie Hazlehurst, Drew B. Day, Ciara Thoreson, Kurunthachalam Kannan, Nicole R. Bush, Kaja Z. LeWinn, Qi Zhao, Sheela Sathyanarayana, Alison G. Paquette

Regrowing the growth zone: metamorphosis kickstarts regeneration in the annelid, Capitella teleta
Alicia A. Boyd, Elaine C. Seaver

Biophysical dissection of SOX18/NR2F2 transcriptional antagonism reveals mechanisms of venous differentiation and drug action in vascular malformation
Matthew S. Graus, Sawan Kumar Jha, Jieqiong Lou, Annegret Holm, Yew Yan Wong, Tara Davidson, Paul Coleman, Ella Sugo, Winnie Luu, Tara Karnezis, Jennifer Gamble, Geoff McCaughan, Scott Nightingale, Joyce Bischoff, Kazuaki Maruyama, Elizabeth Hinde, Kristy Red-Horse, Mathias Francois

A genetically engineered vertebrate animal model of NAA15-related heart disease uncovers myocardial growth, contractility, and mitochondrial defects
Warlen P. Piedade, Olivia Weeks, Alex A. Akerberg, Michael M. Molnar, Jennifer Galdieri, Rongbin Zheng, Kaifu Chen, Hasmik Keshishian, Patrick Hart, Steven A. Carr, Caroline E. Burns, C. Geoffrey Burns

Deletion of KLHDC3, an E3 ubiquitin ligase complex substrate receptor, leads to obesity in mice
Paula Armina V. Buco, Ashfaqul Hoque, Wilson Castillo-Tandazo, Alistair M. Chalk, Monique F. Smeets, Carl R. Walkley

Frem2 Knockout Mice Exhibit Fraser Syndrome Phenotypes and Neonatal Lethality Due to Bilateral Renal Agenesis
Rubina G. Simikyan, Xinyuan Zhang, Olga Strelkova, Nathan Li, MengYu Zhu, Andreas Eckhard, Petr Y. Baranov, Xudong Wu, Lauren Richey, Artur A. Indzhykulian

Engulfing to Adapt: Efferocytosis by Epithelial Cells Triggers Cell State Transitions During Tissue Remodeling
Adda-Lee Graham-Paquin, Deepak Saini, Sophie Viala, Mara KM Whitford, Mathieu Tremblay, William A Pastor, Luke McCaffrey

Niche-targeted therapy via YAP/TAZ activation enhances hematopoietic regeneration
Shun Uemura, Masayuki Yamashita, Takako Yokomizo-Nakano, Ayako Aihara, Takumi Iwawaki, Shuhei Koide, Yaeko Nakajima-Takagi, Motohiko Oshima, Yoshiki Omatsu, Bahityar Rahmutulla, Atsushi Kaneda, Miki Nishio, Akira Suzuki, Takashi Nagasawa, Kenta Kagaya, Taito Nishino, Atsushi Iwama

rapunzel5 is necessary for normal hematopoietic development in zebrafish
S Thapa, W Dowell, E Harris, DL Stachura

Pathogenic DVL frameshifting variants in Robinow syndrome disrupt WNT signaling and cellular dynamics
Chaofan Zhang, Rituparna Sinha Roy, Ming Yin Lun, Juliana F. Mazzeu, Janson White, Wu-Lin Charng, Nathaniel Peters, Jonas A. Gustafson, Harshini Iyer, Zain Dardas, Hyun Kyoung Lee, V. Reid Sutton, James R. Lupski, Claudia M.B. Carvalho

A parenchymal niche regulates pluripotent stem cell function in planarians
Skylar E. Settles, Kathleen E. Miller, Rachel H. Roberts-Galbraith

Longitudinal Live Imaging Derived 4D Hemodynamics and Dynamic Tissue Mechanics Across Outflow Tract Morphogenesis
Gening Dong, Jaehyun Rhee, Shivani Kumar, Molly E. Drumm, Henrik Lauridsen, Mahdi Esmaily-Moghadam, Jonathan T. Butcher

Identification of Human Pluripotent Stem Cell Derived Astrocytic Progenitors that Correlate with Glioblastoma Subtypes
Stephanie Van Gulden, Anne Kathryn Linden, John A. Kessler, Chian-Yu Peng

Transgenic mouse models for investigating human DUX4 expression during development and its roles in FSHD pathophysiology
Yosuke Hiramuki, Charis L. Himeda, Peter L. Jones, Takako I. Jones

Restraint of TGFβ family signaling by SMAD7 is necessary for hematopoietic stem cell maturation in the embryo
Laura F. Bennett, Wenbao Yu, Chia-Hui Chen, Hyun Hyung An, Joanna Tober, Kai Tan, Nancy A. Speck

Single-cell transcriptome identified ddx43+ cell types critical for maintenance of transient slow-cycling stem cells in planaria
Nikhil Kumar Jaligam, Mohamed Mohamed Haroon, Mainak Basu, Atriya Mazumdar, Swathi Pavithran, Vinay Kumar Dubey, Praveen Kumar Vemula, Ankit Arora, Dasaradhi Palakodeti

Adipocyte-Derived Amino Acid Storage Proteins are Required for Germline Stem Cell Maintenance in Adult Drosophila Females
Anna B. Zike, Madison G. Abel, Robert C. Eisman, Lesley N. Weaver

Functional classification of GNAI1 disorder variants in C. elegans uncovers conserved and cell-specific mechanisms of dysfunction
Rehab Salama, Eric Peet, Logan Morrione, Sarah Durant, Maxwell Seager, Madison Rennie, Suzanne Scarlata, Inna Nechipurenko

Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation
Sophia N. Lee, Erin C. Banda, Lu Qiao, Sarah L. Thompson, Karan Singh, Ryan A. Hagenson, Teresa Davoli, Stefan F. Pinter, Jason M. Sheltzer

Single-Cell Characterization of Anterior Segment Development: Cell Types, Pathways, and Signals Driving Formation of the Trabecular Meshwork and Schlemm’s Canal
Revathi Balasubramanian, Nicholas Tolman, Taibo Li, Abdul Hannan, Violet Bupp-Chickering, Karina Polanco, Aakriti Bhandari, Sally Zhou, Marina Simón, John Peregrin, Christa Montgomery, Krishnakumar Kizhatil, Jiang Qian, Simon W.M. John

| Plant development

The Moment Symmetry Breaks: Spatiotemporal Dynamics of CYCLOIDEA Expression During Early Floral Development
Ya Min, Bianca T. Ferreira, Yao-Wu Yuan

Developmental bias explains the evolutionary trend towards simple leaf shapes
James S. Malone, Nora S. Martin, Samuel H. A. von der Dunk, Liliana M. Dávalos, Ard A. Louis

Autophagic degradation of EIN3 ensures developmental plasticity and recovery from environmental stress in Arabidopsis
Jeppe Ansbøl, Isolde Riis, Mette Stub, Rim Chaudhury, Emil Otto Kokholm Nielsen, Jonathan Chevalier, Dominique Van Der Straeten, Zhangli Thomsen Zuo, Sjon Hartman, Eleazar Rodriguez

Spatiotemporal Dynamics of Anionic Phospholipids Orchestrate Lateral Root Initiation and Morphogenesis in Arabidopsis thaliana
Joseph G. Dubrovsky, Juan Li, Sami Bouziri, Eric Bormann, Celine Geiger, Jazmin Reyes-Hernandez, Alexis Maizel

Non-catalytic and catalytic TREHALOSE-6-PHOSPHATE SYNTHASES interact with RAMOSA3 to control maize development
Thu M Tran, Hannes Claeys, María Jazmín Abraham-Juárez, Son L Vi, Xiaosa Xu, Kevin Michalski, Tsung Han Chou, Sessen D Iohannes, Panagiotis Boumpas, Z’Dhanne P Williams, Samatha Sheppard, Cara Griffiths, Matthew J Paul, Hiro Furukawa, David Jackson

WIND1 controls cell fate transition through histone acetylation and deacetylation during somatic embryogenesis
Akira Iwase, Arika Takebayashi, Fu-Yu Hung, Ayako Kawamura, Yetkin Çaka Ince, Yasuhiro Kadota, Soichi Inagaki, Takamasa Suzuki, Ken Shirasu, Keiko Sugimoto

Antagonistic interactions between CLAVATA receptors shape maize ear development
Penelope L. Lindsay, Fang Xu, Lei Liu, Panagiotis Boumpas, Andres Reyes, Byoung Il Je, Mari Ogawa-Ohnishi, Jarrett Man, Tara Skopelitis, Yoshikatsu Matsubayashi, Madelaine Bartlett, Shou-Ling Xu, David Jackson

The mechanical properties of Arabidopsis thaliana roots adapt dynamically during development and to stress
Luis Alonso Baez, Astrid Bjørkøy, Francesco Saffioti, Sara Morghen, Dhika Amanda, Michaela Tichá, Maarten Besten, Anastasiia Ivanova, Joris Sprakel, Bjørn Torger Stokke, Thorsten Hamann

Clathrin-mediated endocytosis of ERECTA family receptors is essential for proper stomatal development in Arabidopsis
Chi Zhang, Liang Chen, Suomin Wang, Chao Wang, Jianwei Pan, Suiwen Hou

The nucleus follows an internal cellular scale during polarized root hair cell development
Jessica Orr, Arif Ashraf

COCHLEATA controls spatial regulation of cytokinin and auxin during nodule development
Karen Velandia, Muhammad Nouman Sohail, Tiana Elizabeth Scott, Alejandro Correa-Lozano, Alannah Mannix, Eloise Foo

Arabidopsis Group I Pumilio RNA-binding factors are vital for embryo development and balancing between growth and stress resistance
Wenjuan Wu, Di Li, Danni Lin, Wangzhi Xu, Tianli Chen, Xiaomei Chen, Wei Guo, Zhengbiao Long, Xiang Xu, Xiaoyu Tu, Jirong Huang

Epigenetic reprogramming guides sexual dimorphism during floral development in Silene latifolia
Tomas Janicek, Vojtech Hudzieczek, Hana Polasek-Sedlackova, Marie Kratka, Vaclav Bacovsky

TCP3-mediated regulation of cell expansion in Arabidopsis thaliana
Tomotsugu Koyama, Tadashi Kunieda, Hiromi Toyonaga, Mika Nobuhara, Nobutaka Mitsuda, Kouichi Soga, Junko Ishida, Motoaki Seki, Koji Takahashi, Toshinori Kinoshita, Ayumu Bessho, Taku Demura, Masaru Ohme-Takagi

PAM18-3, a J-domain protein, maintains mitochondrial integrity and plant growth and development in Arabidopsis thaliana
Neha, S Souparnika, Chandan Sahi

| Environment, evolution and development

The Establishment of Cell-Type Specific Gene Regulation in the Sea Urchin Embryo
Jonas Maurice Brandenburg, Alexandra Trinks, Dominika Voijtasova, Anna Alessandra Monaco, William Chang, Roberto Arsie, Marian Hu, Amro Hamdoun, Chloe Jenniches, Markus Landthaler, Nils Blüthgen, David Aaron Garfield

daf-16/FOXO promotes the activity of ligand-bound DAF-12/NHR to coordinate dauer exit and post-dauer seam cell fate
Matthew J. Wirick, Isaac T. Smith, Benjamin S. Olson, Amelia F. Alessi, Himani Galagali, Kyal Lalk, Mikayla N. Schmidt, Kevin J. Ranke, John K. Kim, Xantha Karp

Temporal orchestration of transcriptional and epigenomic programming underlying maternal embryonic diapause in a cricket model
Kosuke Kataoka, Yuta Shimizu, Ryuto Sanno, Yuichi Koshiishi, Ken Naito, Kei Yura, Toru Asahi, Shin G. Goto

There and back again: the dynamic evolution of panarthropod germ cell specification mechanisms
Jonchee A. Kao, Emily L. Rivard, Rishabh R. Kapoor, Cassandra G. Extavour

Conserved gene expression plasticity in development is more pervasive than expression divergence between species of Caenorhabditis nematodes
Athmaja Viswanath, Daniel D. Fusca, John A. Calarco, Asher D. Cutter

Protein sequence evolution underlies interspecies incompatibility of a cell fate determinant
Emily L. Rivard, John R. Srouji, Anastasia Repouliou, Cassandra G. Extavour

Evolution and Regulation of Decoupled Dimorphic Scaling Patterns in Ants
Erica Vong, Shannon Parisien, Helene Orfali, Rajendhran Rajakumar

Juvenile Hormone Signalling Underlies the Switchpoint and Differentiation of Soldiers in Camponotus floridanus
Olivia MacMillan, Julia Singer, Sophia Perrakis, Alex Craig, Davina Ntanga, David Qiu, Rajendhran Rajakumar

A Synthetic Coolant (WS-23) in Electronic Cigarettes Disrupts Normal Development of Human Embryonic Cells
Shabnam Etemadi, Mohamed Debich, Prue Talbot

Cracking the case: Differential adaptations to hard biting dominate cranial shapein rat-kangaroos (Potoroidae: Bettongia) with divergent diets
Maddison C Randall, Vera Weisbecker, Meg Martin, Kenny Travouillon, Jake Newman-Martin, D. Rex Mitchell

Genome reorganisation and expansion shape 3D genome architecture and define a distinct regulatory landscape in coleoid cephalopods
Thea F. Rogers, Jessica Stock, Natalie Grace Schulz, Gözde Yalçin, Simone Rencken, Anton Weissenbacher, Tereza Clarence, Darrin T. Schultz, Clifton W. Ragsdale, Caroline B. Albertin, Oleg Simakov

Cell Biology

Microtubule acetylation by αTAT1 is essential for touch sensation in zebrafish but dispensable for embryonic development
Samuel G. Bertrand, Daniel T. Grimes

D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport
Masataka Suzuki, Kenichiro Adachi, Pattama Wiriyasermukul, Mariko Fukumura, Ryota Tamura, Yoshinori Hirano, Yumi Aizawa, Tetsuya Miyamoto, Sakiko Taniguchi, Masahiro Toda, Hiroshi Homma, Kohsuke Kanekura, Kenji Yasuoka, Takanori Kanai, Masahiro Sugimoto, Shushi Nagamori, Masato Yasui, Jumpei Sasabe

Ex vivo live imaging unveils the dynamics of oocyte formation in mice
Eishi Aizawa, Junko Hara, Takaya Abe, Tomoya S. Kitajima

The endo-lysosomal system drives lumen formation in a human epiblast model
Anusha Rengarajan, Sicong Wang, Chien-Wei Lin, Amber E. Carleton, Nikola Sekulovski, Linnea E. Taniguchi, Mara C. Duncan, Kenichiro Taniguchi

Mouse pre-meiotic germline cysts contain fusome-like structure dependent on Dazl that mediates cyst fragmentation and oocyte development
Madhulika Pathak, Allan C. Spradling

Spargel/dPGC-1 influences cell growth through the E2F1-mediated endocycle pathway
Md Shah Jalal, Atanu Duttaroy

α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin
Jeanne M. Quinn, Phuong M. Le, Anthea Weng, Annette S. Flozak, S. Sai Folmsbee, Erik Arroyo-Colon, Mitsu Ikura, Noboru Ishiyama, Cara J. Gottardi

Forward Genetics Identifies ptr-18 and Other Genes as Developmental Regulators of the Four-Cell Tail Tip in C. elegans
Uroš Radović, Marcus Henricsson, Jan Borén, Marc Pilon

Spatiotemporal control of cortical centrin patterning by regionalized Sfi1 family scaffolding proteins in Stentor coeruleus
Connie Yan, Niklas Steube, Gautam Dey, Wallace F. Marshall

Membrane-tethered cadherin substrates reveal actin architecture at adherens junctions
Sayantika Ghosh, John James, Badeer Hassan Ummat, Darius Vasco Köster

Regulated development of cannibalistic supergiant cells
Ben T Larson, Daniele Giannotti, Mahara Mtawali, Samuel J. Lord, Vittorio Boscaro, Patrick J. Keeling

Oligomerization and positive feedback on membrane recruitment encode dynamically stable PAR-3 asymmetries in the C. elegans zygote.
Charles F Lang, Ondrej Maxian, Alexander Anneken, Edwin Munro

Zbtb38 transcriptionally activates XIAP to regulate apoptosis in development and cancer
Toshiaki Shigeoka, Hiroyuki Nagaoka, Nunuk Aries Nurulita, Shogo Tada, Yasumasa Bessho, Yasumasa Ishida, Eishou Matsuda

Spatio-temporal control of nuclear mechanotransduction during EMT
Ronan Bouzignac, Amandine Palandri, Amal Zine el Aabidine, Thomas Mangeat, Tatiana Merle, Martine Cazales, Antonio Trullo, Christian Rouviere, Virginia Pimmett, Mounia L Lagha, Magali Suzanne

Capturing trophectoderm-like stem cells enables step-wisely remodeling of placental development
Xinyi Jia, Bing Peng, Hongjin Zhao, Chunhui Wang, Wei Tao, Peng Du

Cell exit during EMT is mechanically triggered independently of E-Cadherin loss
Meritxell Font Noguera, Léa Roquin, Cyril Andrieu, Corinne Benassayag, Bruno Monier, Magali Suzanne

Oocyte polarity is established independently of the Balbiani body
Manami Kobayashi, Joseph Zinski, Mary C. Mullins

SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice
Daisuke Mashiko, Shingo Tonai, Haruhiko Miyata, Martin M. Matzuk, Masahito Ikawa

Modelling

Latent Representations of Early Brain Development: A Multivariate Normative Model of Brain Structure and Behaviour
Mariam Zabihi, Francesca Biondo, Jonathan O’Muircheartaigh, Thomas Wolfers, Sean Deoni, Andre Marquand, Muriel M.K. Bruchhage, James H. Cole

Reconstructing Waddington’s Landscape from Data
Dillon J. Cislo, M. Joaquina Delás, James Briscoe, Eric D. Siggia

Emergent Stable Tissue Shapes from the Regulatory Feedback between Morphogens and Cell Growth
Bivash Kaity, Daniel Lobo

Noise-driven morphogenesis independent of transcriptional regulatory programs
Jack Toppen, Saeed Tavazoie

Tools & Resources

Rapid CE-MS with Real-Time Eco-AI Resolves Proteomic Heterogeneity Among Single Human Neutrophils
Bowen Shen, Fei Zhou, Isabelle Luz, Steven J. Prior, Wagner Fontes, Peter Nemes

7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development
Jucha Willers Moore, Philippa Bridgen, Elisabeth Pickles, Pierluigi Di Cio, Lucy Billimoria, Ines Tomazinho, Cidalia Da Costa, Dario Gallo, Grant Hartung, Alena Uus, Maria Deprez, Sharon L. Giles, A. David Edwards, Jo V. Hajnal, Shaihan J. Malik, Jonathan R. Polimeni, Tomoki Arichi

Trustworthy detection of exencephaly in high-throughput micro-CT embryo screens with focal-loss transformers
Oshane O. Thomas, Rachel Roston, Hongyu Shen, A. Murat Maga

Anatomy-aware, label-informed approach improves image registration for challenging datasets
Rachel A. Roston, Nicholas J. Tustison, A. Murat Maga

A blastocyst-derived in vitro model of the human chorion
Luca C. Schwarz, Matthew J. Shannon, Gina McNeill, Rina C. Sakata, Viviane S. Rosa, Katherine Cheah, Laura Keller, Phil Snell, Leila Christie, Kay Elder, Anastasia Mania, Lauren Weavers, Rachel Gibbons, Tugce Pehlivan Budak, Ippokratis Sarris, Amy Barrie, Alison Campbell, Roser Vento-Tormo, Gary D. Smith, Alexander G. Beristain, Marta N. Shahbazi

Human retinal organoid single-cell atlas allows to reconstruct retinal development at high resolution and identify nature restricted transcriptional states in vitro
Emil Kriukov, Everett Labrecque, Nasrin Refaian, Petr Baranov

Non-segmented unsupervised learning of multispectral whole slide images for robust analysis of tissue repair and regeneration
Kody Paul Mansfield, Tamara Mestvirishvili, Bibi Subhan, Valeria Mezzano-Robinson, Dianny Almanzar, Sydney Hanson, Jimin Tan, Cynthia Loomis, David Fenyo, Aristotelis Tsirigos, Piul S. Rabbani

Smart Microscopy: Current Implementations and a Roadmap for Interoperability
Lucien Hinderling, Hannah S. Heil, Alfredo Rates, Philipp Seidel, Manuel Gunkel, Benedict Diederich, Thomas Guilbert, Rémy Torro, Otmane Bouchareb, Claire Demeautis, Célia Martin, Scott Brooks, Evangelos Sisamakis, Grandgirard Erwan, Karl Johansson, Johannes K. Ahnlinde, Oscar André, Philip Nordenfelt, Pontus Nordenfelt, Claudia Pfander, Jürgen Reymann, Talley Lambert, Marco R. Cosenza, Jan O. Korbel, Rainer Pepperkok, Lukas C. Kapitein, Olivier Pertz, Nils Norlin, Aliaksandr Halavatyi, Rafael Camacho

ShapeSpaceExplorer: Analysis of morphological transitions in migrating cells using similarity-based shape space mapping
Samuel D.R. Jefferyes, Roswitha Gostner, Laura Cooper, Mohammed M. Abdelsamea, Elly Straube, Nasir Rajpoot, David B.A. Epstein, Anne Straube

Real-time feedback control microscopy for automation of optogenetic targeting
Lucien Hinderling, Alex E. Landolt, Benjamin Grädel, Laurent Dubied, Cédric Zahni, Moritz Kwasny, Agne Frismantiene, Talley Lambert, Maciej Dobrzyński, Olivier Pertz

Cell-APP: A generalizable method for cell annotation and cell-segmentation model training
Anish J. Virdi, Ajit P. Joglekar

Improving RNA-seq protocols
Felix Pfoertner, Eva Briem, Wolfgang Enard, Daniel Richter

Low-intensity focused ultrasound enables temporal modulation of human midbrain organoid differentiation
Jinseong Jeong, Yehhyun Jo, Youngsun Lee, Eunyoung Jang, Yeonji Jeong, Won Do Heo, Jennifer H. Shin, Mi-Ok Lee, Hyunjoo J. Lee

A Quantitative Polymerase Chain Reaction Protocol for Sex Identification of Zebra Finch and Chicken Using Blood Samples
Prakrit Subba, Saidat O. Adeniran-Obey, Fanny-Linn Kraft, Susan C. Chapman, Natalie A. Shay, Shannon R. Liedl, Mark D. Wild, Scarlett A. Wolcott, Julia M. George

Neonatal Mouse Ovary Culture: An In Vitro Model for Studying Primordial Follicle Regulation
Edgar A Diaz Miranda, Grace Anne Dyer, Faith Wilson, Mariel English, Taylor VanDeVoorde, Lei Lei

Bridging the gap of late-gestation nephrogenesis using a non-human primate model
Kairavee Thakkar, Sunitha Yarlagadda, Lyan Alkhudairy, Andrew Potter, Konrad Thorner, Praneet Chaturvedi, Kyle W. McCracken, Nathan Salomonis, Raphael Kopan, Meredith P Schuh

Microinjected dsRNA triggers a robust RNAi response in Stentor coeruleus
Makenna Kuecks, Preeti Arra, Sarah Hoffmann-Weitsman, Makenzie Funk Craig, Mark M. Slabodnick

Research practice & education

“Spurring and Siloing: Identity Navigation in Scientific Writing Among Asian Student Researchers”
Devon Goss, Meena Balgopal, Shaila Sachdev, Grace Kim, LaTonia Taliaferro-Smith, Sarah C. Fankhauser

Integrating Career Development and Immigration Planning: A Pilot Program for International Scholars
Caroline Fecher, Natalie Chernets, Paola Cépeda

What drives change? Characterizing scientific self-efficacy development in undergraduate research experiences
Qiyue Zhang, Paul R. Hernandez, Benjamin S. Listyg, Erin L. Dolan

10 recommendations for strengthening citizen science for improved societal and ecological outcomes: A co-produced analysis of challenges and opportunities in the 21st century
Jack Nunn, Håkon da Silva Hyldmo, Lauren McKnight, Heather McCulloch, Jennifer Lavers, Julie Old, Laura Smith, Nicola Grobler, Cheryl Tan Kay Yin, Wing Yan Chan, Candice Raeburn, Nittya S. M. Simard, Adam Kingsley Smith, Sam Van Holsbeeck, Eleanor Drinkwater, Kit Prendergast, Emma Burrows, Christopher L. Lawson

“The ship is going down and we are powerless”: The Impact of Federal Funding Changes on Researchers Training the Next Generation of Scientists
Emily Mastej, Tiffany Do, Arghavan Salles

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